CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.600 | Farnesyl Diphosphate Synthase |
|
1.10.600.10 | Farnesyl Diphosphate Synthase |
Domain Context
CATH Clusters
| Superfamily | Farnesyl Diphosphate Synthase |
| Functional Family |
Enzyme Information
| 4.2.3.9 |
Aristolochene synthase.
based on mapping to UniProt Q9UR08
(2E,6E)-farnesyl diphosphate = aristolochene + diphosphate.
-!- The initial internal cyclization produces the monocyclic intermediate germacrene A; further cyclization and methyl transfer converts the intermediate into aristolochene. -!- While in some species germacrene A remains as an enzyme-bound intermediate, it has been shown to be a minor product of the reaction in Penicillium roqueforti (see also EC 4.2.3.23). -!- Aristolochene is the likely parent compound for a number of sesquiterpenes produced by filamentous fungi. -!- Formerly EC 2.5.1.40 and EC 4.1.99.7.
|
UniProtKB Entries (1)
| Q9UR08 |
ARIS_ASPTE
Aspergillus terreus
Aristolochene synthase
|
PDB Structure
| PDB | 4KUX |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase.
Biochemistry
|
