CATH Domain 4knwA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.120	Four Helix Bundle (Hemerythrin (Met), subunit A)
	1.20.120.710	Haloacid dehalogenase hydrolase-like domain

Domain Context

CATH Clusters

Superfamily	Haloacid dehalogenase hydrolase-like domain
Functional Family	N-acylneuraminate-9-phosphatase

Enzyme Information

3.1.3.29

N-acylneuraminate-9-phosphatase.

based on mapping to UniProt Q8TBE9

N-acylneuraminate 9-phosphate + H(2)O = N-acylneuraminate + phosphate.

UniProtKB Entries (1)

NANP_HUMAN

Homo sapiens

N-acylneuraminate-9-phosphatase

PDB Structure

PDB	4KNW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Design, synthesis, functional and structural characterization of an inhibitor of N-acetylneuraminate-9-phosphate phosphatase: Observation of extensive dynamics in an enzyme/inhibitor complex. Kim, S.H., Constantine, K.L., Duke, G.J., Goldfarb, V., Hunt, J.T., Johnson, S., Kish, K., Klei, H.E., McDonnell, P.A., Metzler, W.J., Mueller, L., Poss, M.A., Fairchild, C.R., Bhide, R.S. Bioorg.Med.Chem.Lett.