CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.600 | Farnesyl Diphosphate Synthase |
|
1.10.600.10 | Farnesyl Diphosphate Synthase |
Domain Context
CATH Clusters
| Superfamily | Farnesyl Diphosphate Synthase |
| Functional Family | Farnesyl pyrophosphate synthase |
Enzyme Information
| 2.5.1.67 |
Chrysanthemyl diphosphate synthase.
based on mapping to UniProt Q7XYS8
2 dimethylallyl diphosphate = diphosphate + chrysanthemyl diphosphate.
-!- Chrysanthemyl diphosphate is a monoterpene with a non-head-to-tail linkage; it is unlike most monoterpenoids, which are derived from geranyl diphosphate and have isoprene units that are linked head- to-tail. -!- The mechanism of its formation is similar to that of the early steps of squalene and phytoene biosynthesis. -!- Chrysanthemyl diphosphate is the precursor of chrysanthemic acid, the acid half of the pyrethroid insecticides found in chrysanthemums.
|
| 2.5.1.1 |
Dimethylallyltranstransferase.
based on mapping to UniProt Q7XYS8
Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
-!- Will not accept larger prenyl diphosphates as efficient donors.
|
| 2.5.1.69 |
Lavandulyl diphosphate synthase.
based on mapping to UniProt Q7XYS8
2 dimethylallyl diphosphate = diphosphate + lavandulyl diphosphate.
-!- Lavandulyl diphosphate is a monoterpene with a non-head-to-tail linkage; it is unlike most monoterpenoids, which are derived from geranyl diphosphate and have isoprene units that are linked head- to-tail. -!- When this enzyme is incubated with dimethylallyl diphosphate and isopentenyl diphosphate, it also forms the regular monoterpene geranyl diphosphate. -!- The enzyme from Artemisia tridentata (big sagebrush) forms both lavandulyl diphosphate and chrysanthemyl diphosphate (see EC 2.5.1.67) when dimethylally diphosphate is the sole substrate.
|
| 2.5.1.1 |
Dimethylallyltranstransferase.
based on mapping to UniProt Q7XYS9
Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
-!- Will not accept larger prenyl diphosphates as efficient donors.
|
| 2.5.1.10 |
(2E,6E)-farnesyl diphosphate synthase.
based on mapping to UniProt Q7XYS9
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)- farnesyl diphosphate.
-!- Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate. -!- The enzyme will not accept larger prenyl diphosphates as efficient donors.
|
UniProtKB Entries (1)
| Q7XYS9 |
FPPS1_ARTSI
Artemisia spiciformis
Farnesyl diphosphate synthase 1
|
PDB Structure
| PDB | 4KK2 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformis (1-72:GI751454468,73-346:GI75233326), apo structure
To be Published
|
