CATH Domain 4kikA01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Inhibitor of nuclear factor kappa-B kinase subunit beta

Enzyme Information

2.7.11.10

I-kappa-B kinase.

based on mapping to UniProt O14920

ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].

-!- Phosphorylates I-kappa-B proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway. -!- Subsequent degradation of the I-kappa-B complex (IKK) activates NF-kappa-B, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis. -!- If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

O14920

IKKB_HUMAN

Homo sapiens

Inhibitor of nuclear factor kappa-B kinase subunit beta

PDB Structure

PDB	4KIK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of a Human I kappa B Kinase beta Asymmetric Dimer. Liu, S., Misquitta, Y.R., Olland, A., Johnson, M.A., Kelleher, K.S., Kriz, R., Lin, L.L., Stahl, M., Mosyak, L. J.Biol.Chem.