CATH Domain 4ka7A01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1370	Neurolysin; domain 3
	1.10.1370.40

Domain Context

CATH Clusters

Superfamily	1.10.1370.40
Functional Family

Enzyme Information

3.4.24.70

Oligopeptidase A.

based on mapping to UniProt Q94AM1

Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)(5).

-!- Differs from thimet oligopeptidase in lack of thiol activation. -!- Belongs to peptidase family M3.

UniProtKB Entries (1)

Q94AM1

OOPDA_ARATH

Arabidopsis thaliana

Organellar oligopeptidase A, chloroplastic/mitochondrial

PDB Structure

PDB	4KA7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Organellar oligopeptidase (OOP) provides a complementary pathway for targeting peptide degradation in mitochondria and chloroplasts. Kmiec, B., Teixeira, P.F., Berntsson, R.P., Murcha, M.W., Branca, R.M., Radomiljac, J.D., Regberg, J., Svensson, L.M., Bakali, A., Langel, U., Lehtio, J., Whelan, J., Stenmark, P., Glaser, E. Proc. Natl. Acad. Sci. U.S.A.