CATH Classification

Domain Context

CATH Clusters

Superfamily Hotdog Thioesterase
Functional Family 1,4-dihydroxy-2-naphthoyl-CoA hydrolase

Enzyme Information

3.1.2.28
1,4-dihydroxy-2-naphthoyl-CoA hydrolase.
based on mapping to UniProt P77781
1,4-dihydroxy-2-naphthoyl-CoA + H(2)O = 1,4-dihydroxy-2-naphthoate + CoA.
-!- This enzyme participates in the synthesis of menaquinones, phylloquinone, as well as several plant pigments. -!- The enzyme from the cyanobacterium Synechocystis sp. PCC 6803 does not accept benzoyl-CoA or phenylacetyl-CoA as substrates. -!- Formerly EC 3.1.2.n1.

UniProtKB Entries (1)

P77781
MENI_ECOLI
Escherichia coli K-12
1,4-dihydroxy-2-naphthoyl-CoA hydrolase

PDB Structure

PDB 4K4B
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and Catalysis in the Escherichia coli Hotdog-fold Thioesterase Paralogs YdiI and YbdB.
Wu, R., Latham, J.A., Chen, D., Farelli, J., Zhao, H., Matthews, K., Allen, K.N., Dunaway-Mariano, D.
Biochemistry