CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.740 | Isoleucyl-tRNA Synthetase; domain 2 |
|
3.90.740.10 | Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain |
Domain Context
CATH Clusters
| Superfamily | Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain |
| Functional Family |
Enzyme Information
| 6.1.1.4 |
Leucine--tRNA ligase.
based on mapping to UniProt B8ZKS5
ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).
|
UniProtKB Entries (1)
| B8ZKS5 |
SYL_STRPJ
Streptococcus pneumoniae ATCC 700669
Leucine--tRNA ligase
|
PDB Structure
| PDB | 4K47 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase
Sci Rep
|