CATH Domain 4k3jB02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1680	ligand-binding face of the semaphorins, domain 2
	3.30.1680.10	ligand-binding face of the semaphorins, domain 2

Domain Context

CATH Clusters

Superfamily	ligand-binding face of the semaphorins, domain 2
Functional Family	Macrophage-stimulating 1 receptor b

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P08581

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P14210

HGF_HUMAN

Homo sapiens

Hepatocyte growth factor

PDB Structure

PDB	4K3J
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent. Merchant, M., Ma, X., Maun, H.R., Zheng, Z., Peng, J., Romero, M., Huang, A., Yang, N.Y., Nishimura, M., Greve, J., Santell, L., Zhang, Y.W., Su, Y., Kaufman, D.W., Billeci, K.L., Mai, E., Moffat, B., Lim, A., Duenas, E.T., Phillips, H.S., Xiang, H., Young, J.C., Vande Woude, G.F., Dennis, M.S., Reilly, D.E., Schwall, R.H., Starovasnik, M.A., Lazarus, R.A., Yansura, D.G. Proc.Natl.Acad.Sci.USA