CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.630.30
Functional Family N-acetylglutamate synthase, mitochondrial

Enzyme Information

2.3.1.1
Amino-acid N-acetyltransferase.
based on mapping to UniProt Q8N159
Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate.
-!- Also acts with L-aspartate and, more slowly, with some other amino acids.

UniProtKB Entries (1)

Q8N159
NAGS_HUMAN
Homo sapiens
N-acetylglutamate synthase, mitochondrial

PDB Structure

PDB 4K30
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the N-acetyltransferase domain of human N-acetyl-L-glutamate synthase in complex with N-acetyl-L-glutamate provides insights into its catalytic and regulatory mechanisms.
Zhao, G., Jin, Z., Allewell, N.M., Tuchman, M., Shi, D.
Plos One