CATH Domain 4jwmA03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.460	Beta Polymerase; domain 2
	3.30.460.10	Beta Polymerase, domain 2

Domain Context

CATH Clusters

Superfamily	Beta Polymerase, domain 2
Functional Family	DNA polymerase beta

Enzyme Information

2.7.7.7	DNA-directed DNA polymerase. based on mapping to UniProt P06746 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
4.2.99.-	Other carbon-oxygen lyases. based on mapping to UniProt P06746

UniProtKB Entries (1)

DPOLB_HUMAN

Homo sapiens

DNA polymerase beta

PDB Structure

PDB	4JWM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Amino Acid Substitution in the Active Site of DNA Polymerase beta Explains the Energy Barrier of the Nucleotidyl Transfer Reaction. Batra, V.K., Perera, L., Lin, P., Shock, D.D., Beard, W.A., Pedersen, L.C., Pedersen, L.G., Wilson, S.H. J.Am.Chem.Soc.