CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.30 | 2-Layer Sandwich |
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3.30.420 | Nucleotidyltransferase; domain 5 |
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3.30.420.10 | Ribonuclease H-like superfamily/Ribonuclease H |
Domain Context
CATH Clusters
Superfamily | Ribonuclease H-like superfamily/Ribonuclease H |
Functional Family | Exodeoxyribonuclease I |
Enzyme Information
3.1.11.1 |
Exodeoxyribonuclease I.
based on mapping to UniProt P04995
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.
-!- Preference for single-stranded DNA. -!- The Escherichia coli enzyme hydrolyzes glucosylated DNA. -!- Similar enzymes; mammalian DNase III, exonuclease IV, T2- and T4-induced exodeoxyribonucleases. -!- Formerly EC 3.1.4.25.
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UniProtKB Entries (1)
P04995 |
EX1_ECOLI
Escherichia coli K-12
Exodeoxyribonuclease I
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PDB Structure
PDB | 4JS4 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal structures of Escherichia coli exonuclease I in complex with single-stranded DNA provide insights into the mechanism of processive digestion.
Nucleic Acids Res.
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