CATH Domain 4jomA03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.10	Arc Repressor Mutant, subunit A
	1.10.10.1600	Bacterial DNA polymerase III alpha subunit, thumb domain

Domain Context

CATH Clusters

Superfamily	Bacterial DNA polymerase III alpha subunit, thumb domain
Functional Family	DNA polymerase III subunit alpha

Enzyme Information

2.7.7.7

DNA-directed DNA polymerase.

based on mapping to UniProt P10443

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P10443

DPO3A_ECOLI

Escherichia coli K-12

DNA polymerase III subunit alpha

PDB Structure

PDB	4JOM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A structural role for the PHP domain in E. coli DNA polymerase III. Barros, T., Guenther, J., Kelch, B., Anaya, J., Prabhakar, A., O Donnell, M., Kuriyan, J., Lamers, M.H. Bmc Struct.Biol.