CATH Domain 4jomA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.140	Metal-dependent hydrolases

Domain Context

CATH Clusters

Superfamily	Metal-dependent hydrolases
Functional Family	DNA polymerase III subunit alpha

Enzyme Information

2.7.7.7

DNA-directed DNA polymerase.

based on mapping to UniProt P10443

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P10443

DPO3A_ECOLI

Escherichia coli K-12

DNA polymerase III subunit alpha

PDB Structure

PDB	4JOM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A structural role for the PHP domain in E. coli DNA polymerase III. Barros, T., Guenther, J., Kelch, B., Anaya, J., Prabhakar, A., O Donnell, M., Kuriyan, J., Lamers, M.H. Bmc Struct.Biol.