CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.8 | Helicase, Ruva Protein; domain 3 |
|
1.10.8.60 |
Domain Context
CATH Clusters
| Superfamily | 1.10.8.60 |
| Functional Family | 4-hydroxy-2-oxovalerate aldolase |
Enzyme Information
| 4.1.3.39 |
4-hydroxy-2-oxovalerate aldolase.
based on mapping to UniProt P9WMK5
(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate.
-!- The enzyme from the bacterium Pseudomonas putida is also stimulated by NADH. -!- In some bacterial species, the enzyme forms a bifunctional complex with EC 1.2.1.10. -!- The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 4.1.3.43.
|
UniProtKB Entries (1)
| P9WMK5 |
HOA_MYCTU
Mycobacterium tuberculosis H37Rv
4-hydroxy-2-oxovalerate aldolase
|
PDB Structure
| PDB | 4JN6 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Characterization of an Aldolase-Dehydrogenase Complex from the Cholesterol Degradation Pathway of Mycobacterium tuberculosis.
Biochemistry
|
