CATH Domain 4jlgB01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.20	Single Sheet
	2.20.110	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
	2.20.110.10	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain

Domain Context

CATH Clusters

Superfamily	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
Functional Family	Histone-lysine N-methyltransferase SETD7

Enzyme Information

2.1.1.43

Histone-lysine N-methyltransferase.

based on mapping to UniProt Q8WTS6

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

SETD7_HUMAN

Homo sapiens

Histone-lysine N-methyltransferase SETD7

PDB Structure

PDB	4JLG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Barsyte-Lovejoy, D., Li, F., Oudhoff, M.J., Tatlock, J.H., Dong, A., Zeng, H., Wu, H., Freeman, S.A., Schapira, M., Senisterra, G.A., Kuznetsova, E., Marcellus, R., Allali-Hassani, A., Kennedy, S., Lambert, J.P., Couzens, A.L., Aman, A., Gingras, A.C., Al-Awar, R., Fish, P.V., Gerstenberger, B.S., Roberts, L., Benn, C.L., Grimley, R.L., Braam, M.J., Rossi, F.M., Sudol, M., Brown, P.J., Bunnage, M.E., Owen, D.R., Zaph, C., Vedadi, M., Arrowsmith, C.H. Proc.Natl.Acad.Sci.USA