CATH Classification
Domain Context
CATH Clusters
Superfamily | Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain |
Functional Family | Histone-lysine N-methyltransferase SETD7 |
Enzyme Information
2.1.1.43 |
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q8WTS6
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
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UniProtKB Entries (1)
Q8WTS6 |
SETD7_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase SETD7
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PDB Structure
PDB | 4JLG |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.
Proc.Natl.Acad.Sci.USA
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