CATH Classification

Domain Context

CATH Clusters

Superfamily EvaA sugar 2,3-dehydratase subunit
Functional Family

Enzyme Information

4.2.1.159
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase.
based on mapping to UniProt O52793
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose = dTDP-3,4-didehydro-2,6- dideoxy-alpha-D-glucose + H(2)O.
-!- The enzyme participates in the biosynthesis of several deoxysugars, including beta-L-4-epi-vancosamine, alpha-L-megosamine, L- and D-olivose, D-oliose, D-mycarose, forosamine and beta-L-digitoxose. -!- In vitro the intermediate can undergo a spontaneous decomposition to maltol.

UniProtKB Entries (1)

O52793
EVAA_AMYOR
Amycolatopsis orientalis
DTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase

PDB Structure

PDB 4J7G
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of EvaA: A Paradigm for Sugar 2,3-Dehydratases.
Kubiak, R.L., Thoden, J.B., Holden, H.M.
Biochemistry