CATH Domain 4ivcA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Tyrosine-protein kinase JAK2

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P23458

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P23458

JAK1_HUMAN

Homo sapiens

Tyrosine-protein kinase JAK1

PDB Structure

PDB	4IVC
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2. Zak, M., Hurley, C.A., Ward, S.I., Bergeron, P., Barrett, K., Balazs, M., Blair, W.S., Bull, R., Chakravarty, P., Chang, C., Crackett, P., Deshmukh, G., Devoss, J., Dragovich, P.S., Eigenbrot, C., Ellwood, C., Gaines, S., Ghilardi, N., Gibbons, P., Gradl, S., Gribling, P., Hamman, C., Harstad, E., Hewitt, P., Johnson, A., Johnson, T., Kenny, J.R., Koehler, M.F., Bir Kohli, P., Labadie, S., Lee, W.P., Liao, J., Liimatta, M., Mendonca, R., Narukulla, R., Pulk, R., Reeve, A., Savage, S., Shia, S., Steffek, M., Ubhayakar, S., van Abbema, A., Aliagas, I., Avitabile-Woo, B., Xiao, Y., Yang, J., Kulagowski, J.J. J.Med.Chem.