CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.70 | Alpha-Beta Plaits |
|
3.30.70.580 | Pseudouridine synthase I, catalytic domain, N-terminal subdomain |
Domain Context
CATH Clusters
| Superfamily | Pseudouridine synthase I, catalytic domain, N-terminal subdomain |
| Functional Family | tRNA pseudouridine synthase |
Enzyme Information
| 5.4.99.12 |
tRNA pseudouridine(38-40) synthase.
based on mapping to UniProt Q9Y606
tRNA uridine(38-40) = tRNA pseudouridine(38-40).
-!- The uridylate residues at positions 38, 39 and 40 of nearly all tRNAs are isomerized to pseudouridine. -!- TruA specifically modifies uridines at positions 38, 39, and/or 40 in the anticodon stem loop of tRNAs with highly divergent sequences and structures.
|
UniProtKB Entries (1)
| Q9Y606 |
TRUA_HUMAN
Homo sapiens
TRNA pseudouridine synthase A
|
PDB Structure
| PDB | 4ITS |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
In Human Pseudouridine Synthase 1 (hPus1), a C-Terminal Helical Insert Blocks tRNA from Binding in the Same Orientation as in the Pus1 Bacterial Homologue TruA, Consistent with Their Different Target Selectivities.
J.Mol.Biol.
|
