CATH Domain 4iquA04

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.210	Beta Polymerase; domain 3
	3.30.210.10	DNA polymerase, thumb domain

Domain Context

CATH Clusters

Superfamily	DNA polymerase, thumb domain
Functional Family	DNA nucleotidylexotransferase

Enzyme Information

3.1.11.-	Exodeoxyribonucleases producing 5'-phosphomonoesters. based on mapping to UniProt P09838
2.7.7.31	DNA nucleotidylexotransferase. based on mapping to UniProt P09838 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes template-independent extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Nucleoside may be ribo- or deoxyribo-.

UniProtKB Entries (1)

TDT_MOUSE

Mus musculus

DNA nucleotidylexotransferase

PDB Structure

PDB	4IQU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target. Costi, R., Cuzzucoli Crucitti, G., Pescatori, L., Messore, A., Scipione, L., Tortorella, S., Amoroso, A., Crespan, E., Campiglia, P., Maresca, B., Porta, A., Granata, I., Novellino, E., Gouge, J., Delarue, M., Maga, G., Di Santo, R. J.Med.Chem.