CATH Domain 4ikfA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.30	Roll
	2.30.30	SH3 type barrels.
	2.30.30.140

Domain Context

CATH Clusters

Superfamily	2.30.30.140
Functional Family

Enzyme Information

3.1.-.-	Acting on ester bonds. based on mapping to UniProt P14350
3.4.23.-	Aspartic endopeptidases. based on mapping to UniProt P14350
2.7.7.49	RNA-directed DNA polymerase. based on mapping to UniProt P14350 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.
3.1.26.4	Ribonuclease H. based on mapping to UniProt P14350 Endonucleolytic cleavage to 5'-phosphomonoester. -!- Acts on RNA-DNA hybrids.
2.7.7.7	DNA-directed DNA polymerase. based on mapping to UniProt P14350 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
2.7.7.-	Nucleotidyltransferases. based on mapping to UniProt P14350

UniProtKB Entries (1)

POL_FOAMV

Human spumaretrovirus

Pro-Pol polyprotein

PDB Structure

PDB	4IKF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	2-Hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs), novel inhibitors of HIV integrase with a high barrier to resistance. Desimmie, B.A., Demeulemeester, J., Suchaud, V., Taltynov, O., Billamboz, M., Lion, C., Bailly, F., Strelkov, S.V., Debyser, Z., Cotelle, P., Christ, F. Acs Chem.Biol.