CATH Classification

Domain Context

CATH Clusters

Superfamily Ureohydrolase domain
Functional Family Arginase-1

Enzyme Information

3.5.3.1
Arginase.
based on mapping to UniProt P05089
L-arginine + H(2)O = L-ornithine + urea.
-!- Also hydrolyzes alpha-N-substituted L-arginines and canavanine.

UniProtKB Entries (1)

P05089
ARGI1_HUMAN
Homo sapiens
Arginase-1

PDB Structure

PDB 4IE1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors.
Golebiowski, A., Paul Beckett, R., Van Zandt, M., Ji, M.K., Whitehouse, D., Ryder, T.R., Jagdmann, E., Andreoli, M., Mazur, A., Padmanilayam, M., Cousido-Siah, A., Mitschler, A., Ruiz, F.X., Podjarny, A., Schroeter, H.
Bioorg.Med.Chem.Lett.