CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family |
Enzyme Information
| 1.3.1.105 |
2-methylene-furan-3-one reductase.
based on mapping to UniProt O23939
4-hydroxy-2,5-dimethylfuran-3(2H)-one + NADP(+) = 4-hydroxy-5-methyl-2- methylenefuran-3(2H)-one + NADPH.
-!- The enzyme was dicovered in strawberry (Fragaria x ananassa), where it produces furaneol, one of the major aroma compounds in the fruits. -!- It has also been detected in tomato (Solanum lycopersicum) and pineapple (Ananas comosus). -!- The enzyme can also act on derivatives substituted at the methylene functional group. -!- The enzyme from the yeast Saccharomyces cerevisiae acts on (2E)-2- ethylidene-4-hydroxy-5-methylfuran-3(2H)-one and produces homofuraneol, an important aroma compound in soy sauce and miso. -!- NADPH is the preferred cofactor.
|
UniProtKB Entries (1)
| O23939 |
ENOX_FRAVE
Fragaria vesca
2-methylene-furan-3-one reductase
|
PDB Structure
| PDB | 4IDC |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis for the enzymatic formation of the key strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone
J.Biol.Chem.
|
