CATH Domain 4id7A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Putative activated CDC42 kinase 1

Enzyme Information

2.7.11.1	Non-specific serine/threonine protein kinase. based on mapping to UniProt Q07912 ATP + a protein = ADP + a phosphoprotein. -!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
2.7.10.2	Non-specific protein-tyrosine kinase. based on mapping to UniProt Q07912 ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. -!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

ACK1_HUMAN

Homo sapiens

Activated CDC42 kinase 1

PDB Structure

PDB	4ID7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of potent, selective and orally bioavailable imidazo[1,5-a]pyrazine derived ACK1 inhibitors. Jin, M., Wang, J., Kleinberg, A., Kadalbajoo, M., Siu, K.W., Cooke, A., Bittner, M.A., Yao, Y., Thelemann, A., Ji, Q., Bhagwat, S., Mulvihill, K.M., Rechka, J.A., Pachter, J.A., Crew, A.P., Epstein, D., Mulvihill, M.J. Bioorg.Med.Chem.Lett.