CATH Domain 4i9zA00

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1300	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
	1.10.1300.10	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Superfamily	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family	Phosphodiesterase

3.1.4.35

3',5'-cyclic-GMP phosphodiesterase.

based on mapping to UniProt O76074

Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

PDE5A_HUMAN

Homo sapiens

CGMP-specific 3',5'-cyclic phosphodiesterase

PDB	4I9Z
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5. Gong, X., Wang, G., Ren, J., Liu, Z., Wang, Z., Chen, T., Yang, X., Jiang, X., Shen, J., Jiang, H., Aisa, H.A., Xu, Y., Li, J. Bioorg.Med.Chem.Lett.