CATH Classification

Domain Context

CATH Clusters

Superfamily Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain
Functional Family

Enzyme Information

1.1.1.88
Hydroxymethylglutaryl-CoA reductase.
based on mapping to UniProt P13702
(R)-mevalonate + CoA + 2 NAD(+) = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH.

UniProtKB Entries (1)

P13702
MVAA_PSEMV
Pseudomonas mevalonii
3-hydroxy-3-methylglutaryl-coenzyme A reductase

PDB Structure

PDB 4I56
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Steussy, C.N., Critchelow, C.J., Schmidt, T., Min, J.K., Wrensford, L.V., Burgner, J.W., Rodwell, V.W., Stauffacher, C.V.
Biochemistry
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