CATH Domain 4i4bA01

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.770	3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
	3.90.770.10	3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2

Superfamily	3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
Functional Family

1.1.1.88

Hydroxymethylglutaryl-CoA reductase.

based on mapping to UniProt P13702

(R)-mevalonate + CoA + 2 NAD(+) = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH.

MVAA_PSEMV

Pseudomonas mevalonii

3-hydroxy-3-methylglutaryl-coenzyme A reductase

PDB	4I4B
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase. Steussy, C.N., Critchelow, C.J., Schmidt, T., Min, J.K., Wrensford, L.V., Burgner, J.W., Rodwell, V.W., Stauffacher, C.V. Biochemistry