CATH Domain 4i0tA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Tyrosine-protein kinase SYK

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P43405

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P43405

KSYK_HUMAN

Homo sapiens

Tyrosine-protein kinase SYK

PDB Structure

PDB	4I0T
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors. Padilla, F., Bhagirath, N., Chen, S., Chiao, E., Goldstein, D.M., Hermann, J.C., Hsu, J., Kennedy-Smith, J.J., Kuglstatter, A., Liao, C., Liu, W., Lowrie, L.E., Luk, K.C., Lynch, S.M., Menke, J., Niu, L., Owens, T.D., O-Yang, C., Railkar, A., Schoenfeld, R.C., Slade, M., Steiner, S., Tan, Y.C., Villasenor, A.G., Wang, C., Wanner, J., Xie, W., Xu, D., Zhang, X., Zhou, M., Lucas, M.C. J.Med.Chem.