CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.20 | Plasminogen Kringle 4 |
|
2.40.20.10 | Plasminogen Kringle 4 |
Domain Context
CATH Clusters
| Superfamily | Plasminogen Kringle 4 |
| Functional Family | Prothrombin |
Enzyme Information
| 3.4.21.5 |
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.
|
UniProtKB Entries (1)
| P00734 |
THRB_HUMAN
Homo sapiens
Prothrombin
|
PDB Structure
| PDB | 4HZH |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of prothrombin reveals conformational flexibility and mechanism of activation.
J.Biol.Chem.
|
