CATH Domain 4hvsA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Mast/stem cell growth factor receptor

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P10721

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P10721

KIT_HUMAN

Homo sapiens

Mast/stem cell growth factor receptor Kit

PDB Structure

PDB	4HVS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor. Zhang, C., Ibrahim, P.N., Zhang, J., Burton, E.A., Habets, G., Zhang, Y., Powell, B., West, B.L., Matusow, B., Tsang, G., Shellooe, R., Carias, H., Nguyen, H., Marimuthu, A., Zhang, K.Y., Oh, A., Bremer, R., Hurt, C.R., Artis, D.R., Wu, G., Nespi, M., Spevak, W., Lin, P., Nolop, K., Hirth, P., Tesch, G.H., Bollag, G. Proc.Natl.Acad.Sci.USA