CATH Domain 4hgtA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family

Enzyme Information

2.7.11.1	Non-specific serine/threonine protein kinase. based on mapping to UniProt P48730 ATP + a protein = ADP + a phosphoprotein. -!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
2.7.11.26	[Tau protein] kinase. based on mapping to UniProt P48730 ATP + [tau protein] = ADP + [tau protein] phosphate. -!- Activated by tubulin. -!- Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease. -!- Formerly EC 2.7.1.135.

UniProtKB Entries (1)

KC1D_HUMAN

Homo sapiens

Casein kinase I isoform delta

PDB Structure

PDB	4HGT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Based Design of Potent and Selective CK1 gamma Inhibitors. Huang, H., Acquaviva, L., Berry, V., Bregman, H., Chakka, N., O'Connor, A., DiMauro, E.F., Dovey, J., Epstein, O., Grubinska, B., Goldstein, J., Gunaydin, H., Hua, Z., Huang, X., Huang, L., Human, J., Long, A., Newcomb, J., Patel, V.F., Saffran, D., Serafino, R., Schneider, S., Strathdee, C., Tang, J., Turci, S., White, R., Yu, V., Zhao, H., Wilson, C., Martin, M.W. ACS Med Chem Lett