CATH Domain 4hbpA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1300	Amidase signature (AS) enzymes
	3.90.1300.10	Amidase signature (AS) domain

Domain Context

CATH Clusters

Superfamily	Amidase signature (AS) domain
Functional Family	Fatty-acid amide hydrolase 1

Enzyme Information

3.5.1.99

Fatty acid amide hydrolase.

based on mapping to UniProt P97612

(1) Anandamide + H(2)O = arachidonic acid + ethanolamine. (2) Oleamide + H(2)O = oleic acid + NH(3).

-!- Integral membrane protein, the enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide, occurs in mammalia. -!- Formerly EC 3.5.1.n2.

UniProtKB Entries (1)

P97612

FAAH1_RAT

Rattus norvegicus

Fatty-acid amide hydrolase 1

PDB Structure

PDB	4HBP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors. Kono, M., Matsumoto, T., Kawamura, T., Nishimura, A., Kiyota, Y., Oki, H., Miyazaki, J., Igaki, S., Behnke, C.A., Shimojo, M., Kori, M. Bioorg.Med.Chem.