CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.140 | Butyryl-CoA Dehydrogenase, subunit A; domain 3 |
|
1.20.140.20 | Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain |
Domain Context
CATH Clusters
| Superfamily | Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain |
| Functional Family | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial |
Enzyme Information
| 2.7.11.4 |
[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase.
based on mapping to UniProt Q00972
ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] = ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate.
-!- Has no activating compound but is specific for its substrate. -!- A mitochondrial enzyme associated with the branched-chain 2-oxoacid dehydrogenase complex. -!- Phosphorylation inactivates EC 1.2.4.4. -!- Formerly EC 2.7.1.115.
|
UniProtKB Entries (1)
| Q00972 |
BCKD_RAT
Rattus norvegicus
[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial
|
PDB Structure
| PDB | 4H85 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase.
Proc.Natl.Acad.Sci.USA
|
