CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.220 |
Domain Context
CATH Clusters
| Superfamily | 3.20.20.220 |
| Functional Family | Proline dehydrogenase |
Enzyme Information
| 1.5.5.2 |
Proline dehydrogenase.
based on mapping to UniProt Q9RW55
L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol.
-!- The electrons from L-proline are transferred to the FAD cofactor, and from there to a quinone acceptor. -!- In many organisms, ranging from bacteria to mammals, proline is oxidized to glutamate in a two-step process involving this enzyme and EC 1.2.1.88. -!- Both activities are carried out by the same enzyme in enterobacteria. -!- Formerly EC 1.5.99.8.
|
UniProtKB Entries (1)
| Q9RW55 |
PRODH_DEIRA
Deinococcus radiodurans R1
Proline dehydrogenase
|
PDB Structure
| PDB | 4H6Q |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structures and kinetics of monofunctional proline dehydrogenase provide insight into substrate recognition and conformational changes associated with flavin reduction and product release.
Biochemistry
|
