CATH Domain 4h3cA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1180	Undecaprenyl pyrophosphate synthetase
	3.40.1180.10	Decaprenyl diphosphate synthase-like

Domain Context

CATH Clusters

Superfamily	Decaprenyl diphosphate synthase-like
Functional Family	(2E,6E)-farnesyl-diphosphate-specific ditrans,polycis-undecaprenyl-diphosphate synthase

Enzyme Information

2.5.1.31

Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl- diphosphate specific).

based on mapping to UniProt P60472

(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = 8 diphosphate + di-trans,octa-cis-undecaprenyl diphosphate.

-!- Undecaprenyl pyrophosphate synthase catalyzes the consecutive condensation reactions of a farnesyl diphosphate with eight isopentenyl diphosphates, in which new cis-double bonds are formed, to generate undecaprenyl diphosphate that serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall.

UniProtKB Entries (1)

P60472

UPPS_ECOLI

Escherichia coli K-12

Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)

PDB Structure

PDB	4H3C
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Antibacterial drug leads targeting isoprenoid biosynthesis. Zhu, W., Zhang, Y., Sinko, W., Hensler, M.E., Olson, J., Molohon, K.J., Lindert, S., Cao, R., Li, K., Wang, K., Wang, Y., Liu, Y.L., Sankovsky, A., de Oliveira, C.A., Mitchell, D.A., Nizet, V., McCammon, J.A., Oldfield, E. Proc.Natl.Acad.Sci.USA