CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.390 | Collagenase (Catalytic Domain) |
|
3.40.390.10 | Collagenase (Catalytic Domain) |
Domain Context
CATH Clusters
| Superfamily | Collagenase (Catalytic Domain) |
| Functional Family | Meprin A subunit |
Enzyme Information
| 3.4.24.63 |
Meprin B.
based on mapping to UniProt Q16820
Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of 5-His-|-Leu-6, 6-Leu-|-Cys-7, 14-Ala-|-Leu-15 and 19-Cys-|-Gly-20 bonds in insulin B chain.
-!- Inhibited by EDTA and 1,10-phenanthroline, but not by phosphoramidon, captopril or thiorphan. -!- Belongs to peptidase family M12A.
|
UniProtKB Entries (1)
| Q16820 |
MEP1B_HUMAN
Homo sapiens
Meprin A subunit beta
|
PDB Structure
| PDB | 4GWN |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis for the sheddase function of human meprin beta metalloproteinase at the plasma membrane
Proc.Natl.Acad.Sci.USA
|