CATH Domain 4gsfB04

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.830	Cytochrome Bc1 Complex; Chain A, domain 1
	3.30.830.10	Metalloenzyme, LuxS/M16 peptidase-like

Domain Context

CATH Clusters

Superfamily	Metalloenzyme, LuxS/M16 peptidase-like
Functional Family	Insulin-degrading enzyme

Enzyme Information

3.4.24.56

Insulysin.

based on mapping to UniProt P14735

Degradation of insulin, glucagon and other polypeptides. No action on proteins.

-!- Cytosolic enzyme, known from mammals and Drosophila melanogaster. -!- Inhibited by bacitracin, chelating agents EDTA and 1,10- phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not by phosphoramidon. -!- Belongs to peptidase family M16. -!- Formerly EC 3.4.22.11, EC 3.4.99.10 and EC 3.4.99.45.

UniProtKB Entries (1)

P14735

IDE_HUMAN

Homo sapiens

Insulin-degrading enzyme

PDB Structure

PDB	4GSF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme. Charton, J., Gauriot, M., Totobenazara, J., Hennuyer, N., Dumont, J., Bosc, D., Marechal, X., Elbakali, J., Herledan, A., Wen, X., Ronco, C., Gras-Masse, H., Heninot, A., Pottiez, V., Landry, V., Staels, B., Liang, W.G., Leroux, F., Tang, W.J., Deprez, B., Deprez-Poulain, R. Eur.J.Med.Chem.