CATH Classification

Domain Context

CATH Clusters

Superfamily Aldehyde Dehydrogenase; Chain A, domain 2
Functional Family Cytosolic 10-formyltetrahydrofolate dehydrogenase

Enzyme Information

1.5.1.6
Formyltetrahydrofolate dehydrogenase.
based on mapping to UniProt P28037
10-formyltetrahydrofolate + NADP(+) + H(2)O = tetrahydrofolate + CO(2) + NADPH.

UniProtKB Entries (1)

P28037
AL1L1_RAT
Rattus norvegicus
Cytosolic 10-formyltetrahydrofolate dehydrogenase

PDB Structure

PDB 4GNZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The mechanism of discrimination between oxidized and reduced coenzyme in the aldehyde dehydrogenase domain of Aldh1l1.
Tsybovsky, Y., Malakhau, Y., Strickland, K.C., Krupenko, S.A.
Chem.Biol.Interact
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