CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.300 | P-loop containing nucleotide triphosphate hydrolases |
Domain Context
CATH Clusters
| Superfamily | P-loop containing nucleotide triphosphate hydrolases |
| Functional Family | Interferon-induced with helicase C domain 1 |
Enzyme Information
| 3.6.4.13 |
RNA helicase.
based on mapping to UniProt Q9BYX4
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).
|
UniProtKB Entries (1)
| Q9BYX4 |
IFIH1_HUMAN
Homo sapiens
Interferon-induced helicase C domain-containing protein 1
|
PDB Structure
| PDB | 4GL2 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5.
Cell(Cambridge,Mass.)
|