CATH Classification
Domain Context
CATH Clusters
| Superfamily | Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain |
| Functional Family | Anthranilate phosphoribosyltransferase |
Enzyme Information
| 2.4.2.18 |
Anthranilate phosphoribosyltransferase.
based on mapping to UniProt P9WFX5
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 4.1.1.48, EC 4.1.3.27, EC 4.2.1.20 and EC 5.3.1.24).
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UniProtKB Entries (1)
| P9WFX5 |
TRPD_MYCTU
Mycobacterium tuberculosis H37Rv
Anthranilate phosphoribosyltransferase
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PDB Structure
| PDB | 4GIU |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.
Chembiochem
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