CATH Domain 4giiA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Tyrosine-protein kinase JAK2

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P29597

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P29597

TYK2_HUMAN

Homo sapiens

Non-receptor tyrosine-protein kinase TYK2

PDB Structure

PDB	4GII
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors. Liang, J., van Abbema, A., Balazs, M., Barrett, K., Berezhkovsky, L., Blair, W., Chang, C., Delarosa, D., Devoss, J., Driscoll, J., Eigenbrot, C., Ghilardi, N., Gibbons, P., Halladay, J., Johnson, A., Kohli, P.B., Lai, Y., Liu, Y., Lyssikatos, J., Mantik, P., Menghrajani, K., Murray, J., Peng, I., Sambrone, A., Shia, S., Shin, Y., Smith, J., Sohn, S., Tsui, V., Ultsch, M., Wu, L.C., Xiao, Y., Yang, W., Young, J., Zhang, B., Zhu, B.Y., Magnuson, S. J.Med.Chem.