CATH Domain 4gfdA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	Thymidylate kinase

Enzyme Information

2.7.4.9

dTMP kinase.

based on mapping to UniProt P65248

ATP + dTMP = ADP + dTDP.

UniProtKB Entries (1)

KTHY_STAAM

Staphylococcus aureus subsp. aureus Mu50

Thymidylate kinase

PDB Structure

PDB	4GFD
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	In Vivo Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound. Keating, T.A., Newman, J.V., Olivier, N.B., Otterson, L.G., Andrews, B., Boriack-Sjodin, P.A., Breen, J.N., Doig, P., Dumas, J., Gangl, E., Green, O.M., Guler, S.Y., Hentemann, M.F., Joseph-McCarthy, D., Kawatkar, S., Kutschke, A., Loch, J.T., McKenzie, A.R., Pradeepan, S., Prasad, S., Martinez-Botella, G. Acs Chem.Biol.