CATH Domain 4gebA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.640	Aspartate Aminotransferase; domain 2
	3.40.640.10	Type I PLP-dependent aspartate aminotransferase-like (Major domain)

Domain Context

CATH Clusters

Superfamily	Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family

Enzyme Information

2.6.1.7	Kynurenine--oxoglutarate transaminase. based on mapping to UniProt Q8N5Z0 L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate. -!- Also acts on 3-hydroxykynurenine. -!- The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.
2.6.1.39	2-aminoadipate transaminase. based on mapping to UniProt Q8N5Z0 L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate.

UniProtKB Entries (1)

AADAT_HUMAN

Homo sapiens

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

PDB Structure

PDB	4GEB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency. Dounay, A.B., Anderson, M., Bechle, B.M., Evrard, E., Gan, X., Kim, J.Y., McAllister, L.A., Pandit, J., Rong, S., Salafia, M.A., Tuttle, J.B., Zawadzke, L.E., Verhoest, P.R. Bioorg.Med.Chem.Lett.