CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family

Enzyme Information

2.6.1.7
Kynurenine--oxoglutarate transaminase.
based on mapping to UniProt Q8N5Z0
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
-!- Also acts on 3-hydroxykynurenine. -!- The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.
2.6.1.39
2-aminoadipate transaminase.
based on mapping to UniProt Q8N5Z0
L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate.

UniProtKB Entries (1)

Q8N5Z0
AADAT_HUMAN
Homo sapiens
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

PDB Structure

PDB 4GDY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of Hydroxamate Bioisosteres as KATII Inhibitors with Improved Oral Bioavailability and Pharmacokinetics
Verhoest, P.R., Henderson, J.L., Sawant-Basak, A., Tuttle, J.B., Dounay, A.B., McAllister, L.A., Pandit, J., Rong, S., Hou, X., Bechle, B., Parikh, V., Evrard, E., Ghosh, S., Salafia, M.A., Rago, B., Obach, R., Fonseca, K.R., Chang, C.
MEDCHEMCOMM