CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.1170 | Aldehyde Oxidoreductase; domain 3 |
|
3.90.1170.30 | Pyrimidine nucleoside phosphorylase-like, C-terminal domain |
Domain Context
CATH Clusters
| Superfamily | Pyrimidine nucleoside phosphorylase-like, C-terminal domain |
| Functional Family | AMP phosphorylase |
Enzyme Information
| 2.4.2.57 |
AMP phosphorylase.
based on mapping to UniProt Q5JCX3
(1) AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate. (2) CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate. (3) UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.
-!- The enzyme from archaea is involved in AMP metabolism and CO(2) fixation through type III RubisCO enzymes. -!- The activity with CMP and UMP requires activation by cAMP.
|
UniProtKB Entries (1)
| Q5JCX3 |
AMPPA_THEKO
Thermococcus kodakarensis KOD1
AMP phosphorylase
|
PDB Structure
| PDB | 4GA6 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure analysis of archaeal AMP phosphorylase reveals two unique modes of dimerization
J.Mol.Biol.
|