CATH Domain 4g17A02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt Q9Y6M4

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q9Y6M4

KC1G3_HUMAN

Homo sapiens

Casein kinase I isoform gamma-3

PDB Structure

PDB	4G17
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1g)inhibitors Hua, Z., Huang, X., Bregman, H., Chakka, N., DiMauro, E.F., Doherty, E.M., Goldstein, J., Gunaydin, H., Huang, H., Mercede, S., Newcomb, J., Patel, V.F., Turci, S.M., Yan, J., Wilson, C., Martin, M.W. Bioorg.Med.Chem.Lett.