CATH Domain 4fsfA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.450	Beta-Lactamase
	3.30.450.330

Domain Context

CATH Clusters

Superfamily	3.30.450.330
Functional Family	Peptidoglycan D,D-transpeptidase FtsI

Enzyme Information

3.4.16.4

Serine-type D-Ala-D-Ala carboxypeptidase.

based on mapping to UniProt Q51504

Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.

-!- A group of bacterial enzymes, membrane-bound. -!- Inhibited by beta-lactam antibiotics, which acylate the active site serine in the enzyme. -!- Distinct from EC 3.4.17.14. -!- Belongs to peptidase families S11, S12 and S13.

UniProtKB Entries (1)

Q51504

Q51504_PSEAI

Pseudomonas aeruginosa

Peptidoglycan D,D-transpeptidase FtsI

PDB Structure

PDB	4FSF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections. Mitton-Fry, M.J., Arcari, J.T., Brown, M.F., Casavant, J.M., Finegan, S.M., Flanagan, M.E., Gao, H., George, D.M., Gerstenberger, B.S., Han, S., Hardink, J.R., Harris, T.M., Hoang, T., Huband, M.D., Irvine, R., Lall, M.S., Megan Lemmon, M., Li, C., Lin, J., McCurdy, S.P., Mueller, J.P., Mullins, L., Niosi, M., Noe, M.C., Pattavina, D., Penzien, J., Plummer, M.S., Risley, H., Schuff, B.P., Shanmugasundaram, V., Starr, J.T., Sun, J., Winton, J., Young, J.A. Bioorg.Med.Chem.Lett.