CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.70.270
Functional Family Polymerase (DNA directed) iota

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt Q9UNA4
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q9UNA4
POLI_HUMAN
Homo sapiens
DNA polymerase iota

PDB Structure

PDB 4FS2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Basis of Miscoding of the DNA Adduct N2,3-Ethenoguanine by Human Y-family DNA Polymerases.
Zhao, L., Pence, M.G., Christov, P.P., Wawrzak, Z., Choi, J.Y., Rizzo, C.J., Egli, M., Guengerich, F.P.
J.Biol.Chem.
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