CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.1410 | Poly(a)-polymerase, middle domain |
|
1.10.1410.10 |
Domain Context
CATH Clusters
| Superfamily | 1.10.1410.10 |
| Functional Family | Terminal uridylyltransferase cid1 |
Enzyme Information
| 2.7.7.19 |
Polynucleotide adenylyltransferase.
based on mapping to UniProt O13833
ATP + RNA(n) = diphosphate + RNA(n+1).
-!- Also acts slowly with CTP. -!- Catalyzes template-independent extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- The primer, depending on the source of the enzyme, may be an RNA or DNA fragment or oligo(A) bearing a 3'-OH terminal group. -!- See also EC 2.7.7.6.
|
| 2.7.7.52 |
RNA uridylyltransferase.
based on mapping to UniProt O13833
UTP + RNA(n) = diphosphate + RNA(n+1).
-!- Requires an oligoribonucleotide or polyribonucleotide with a free terminal 3'-OH as a primer.
|
UniProtKB Entries (1)
| O13833 |
CID1_SCHPO
Schizosaccharomyces pombe 972h-
Terminal uridylyltransferase cid1
|
PDB Structure
| PDB | 4FHX |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structures of the Cid1 poly (U) polymerase reveal the mechanism for UTP selectivity.
Nucleic Acids Res.
|
