CATH Domain 4fe3A02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.150	DNA polymerase; domain 1
	1.10.150.340	Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain

Domain Context

CATH Clusters

Superfamily	Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain
Functional Family	Cytosolic 5-nucleotidase 3-like

Enzyme Information

3.1.3.5	5'-nucleotidase. based on mapping to UniProt Q9D020 A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate. -!- Wide specificity for 5'-nucleotides.
3.1.3.91	7-methylguanosine nucleotidase. based on mapping to UniProt Q9D020 (1) N(7)-methyl-GMP + H(2)O = N(7)-methyl-guanosine + phosphate. (2) CMP + H(2)O = cytidine + phosphate. -!- The enzyme also has low activity with N(7)-methyl-GDP, producing N(7)-methyl-GMP. -!- Does not accept AMP or GMP, and has low activity with UMP.

UniProtKB Entries (1)

5NT3A_MOUSE

Mus musculus

Cytosolic 5'-nucleotidase 3A

PDB Structure

PDB	4FE3
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Basis of Substrate Specificity and Selectivity of Murine Cytosolic 5'-Nucleotidase III. Grobosky, C.L., Lopez, J.B., Rennie, S., Skopelitis, D.J., Wiest, A.T., Bingman, C.A., Bitto, E. J.Mol.Biol.